Review of: Programma Star

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Zur Handlung: Eine Horde Teenies will 24 Stunden in dem unheimlichen Gebude in der Nhe von Berlin ausharren, machen die ihm eine schockierende Diagnose: Er hat einen bsartigen Gehirntumor.

Programma Star

Übersetzung im Kontext von „het energy star-programma“ in Niederländisch-​Deutsch von Reverso Context: Deelneming aan het Energy Star-programma. Categoria: Werbesendung; Informazioni sulla produzione: Teleshopping; Paese di produzione: D; Anno di produzione: ; Descrizione: Teleshopping mit. La guida ai programmi TV attuale per Star TV e molti altri. Dacci una spulciata subito, consultala immediatamente e gratuitamente online oppure registrala!

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Programma Star Department of Taxation and Finance Video

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Programma Star
Programma Star If you’ve recently bought your home or you’ve never applied for the STAR benefit on your current home, you may be able to save hundreds of dollars each year. You only need to register for the STAR credit once, and you’ll continue to receive the annual benefit as long as you’re eligible. See the STAR program to learn more. Westchester County; Municipality Enhanced exemption Basic exemption Date certified; City of Mt Vernon: $5, $2, 10/23/ City of New Rochelle: $4, The STAR Program (Strategies for Teaching based on Autism Research, Arick, Loos, Falco, Krug, ) teaches children with autism the critical skills identified by the National Research Council and uses many of the evidence-based practices identified in the National Standards Report and National Professional Development Report. Ταινίες, ενημέρωση, ψυχαγωγία, σειρές, Starland, live streaming. Όλα τα αγαπημένα σου προγράμματα εδώ!. The STAR program continues to provide much- needed property tax relief to New York State’s homeowners. New applicants who qualify for STAR will register with New York State instead of applying with their assessor.
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Technical criticism [45] based upon unclassified calculations suggested that the X-ray laser would be of at best marginal use for missile defense. Despite the apparent failure of the Cabra test, the long term legacy of the X-ray laser program is the knowledge gained while conducting the research.

A parallel developmental program advanced laboratory X-ray lasers [47] for biological imaging and the creation of 3D holograms of living organisms.

Other spin-offs include research on advanced materials like SEAgel and Aerogel , the Electron-Beam Ion Trap facility for physics research, and enhanced techniques for early detection of breast cancer.

Beginning in , the Air Force tested an SDIO-funded deuterium fluoride laser known as Mid-Infrared Advanced Chemical Laser MIRACL at White Sands Missile Range.

During a simulation, the laser successfully destroyed a Titan missile booster in , however the test setup had the booster shell pressurized and under considerable compression loads.

After the SDIO closed, the MIRACL was tested on an old Air Force satellite for potential use as an anti-satellite weapon , with mixed results.

During the mid-to-late s a number of panel discussions on lasers and SDI took place at various laser conferences. The Missile Defense Agency 's Airborne Laser program uses a chemical laser which has successfully intercepted a missile taking off, [51] so an offshoot of SDI could be said to have successfully implemented one of the key goals of the program.

In July , the Beam Experiments Aboard a Rocket BEAR program launched a sounding rocket containing a neutral particle beam NPB accelerator.

The experiment successfully demonstrated that a particle beam would operate and propagate as predicted outside the atmosphere and that there are no unexpected side-effects when firing the beam in space.

After the rocket was recovered, the particle beam was still operational. The High Precision Tracking Experiment HPTE , launched with the Space Shuttle Discovery on STSG , was tested June 21, when a Hawaii-based low-power laser successfully tracked the experiment and bounced the laser off of the HPTE mirror.

The Relay mirror experiment RME , launched in February , demonstrated critical technologies for space-based relay mirrors that would be used with an SDI directed-energy weapon system.

Launched on the same rocket as the RME, the Low-power Atmospheric Compensation Experiment LACE satellite was built by the United States Naval Research Laboratory NRL to explore atmospheric distortion of lasers and real-time adaptive compensation for that distortion.

The LACE satellite also included several other experiments to help develop and improve SDI sensors, including target discrimination using background radiation and tracking ballistic missiles using Ultraviolet Plume Imaging UVPI.

Research out of hypervelocity railgun technology was done to build an information base about railguns so that SDI planners would know how to apply the technology to the proposed defense system.

The SDI railgun investigation, called the Compact High Energy Capacitor Module Advanced Technology Experiment, had been able to fire two projectiles per day during the initiative.

This represented a significant improvement over previous efforts, which were only able to achieve about one shot per month.

Hypervelocity railguns are, at least conceptually, an attractive alternative to a space-based defense system because of their envisioned ability to quickly shoot at many targets.

Also, since only the projectile leaves the gun, a railgun system can potentially fire many times before needing to be resupplied.

A hypervelocity railgun works very much like a particle accelerator insofar as it converts electrical potential energy into kinetic energy imparted to the projectile.

A conductive pellet the projectile is attracted down the rails by electric current flowing through a rail. Through the magnetic forces that this system achieves, a force is exerted on the projectile moving it down the rail.

Railguns can generate muzzle-velocities in excess of 2. Railguns face a host of technical challenges before they will be ready for battlefield deployment.

First, the rails guiding the projectile must carry very high power. Each firing of the railgun produces tremendous current flow almost half a million amperes through the rails, causing rapid erosion of the rail's surfaces through ohmic heating , and even vaporization of the rail surface.

Early prototypes were essentially single-use weapons, requiring complete replacement of the rails after each firing.

Another challenge with the railgun system is projectile survivability. To be effective, the fired projectile must first survive the mechanical stress of firing and the thermal effects of a trip through the atmosphere at many times the speed of sound before its subsequent impact with the target.

In-flight guidance, if implemented, would require the onboard navigation system to be built to the same level of sturdiness as the main mass of the projectile.

In addition to being considered for destroying ballistic missile threats, railguns were also being planned for service in space platform sensor and battle station defense.

This potential role reflected defense planner expectations that the railguns of the future would be capable of not only rapid fire, but also of multiple firings on the order of tens to hundreds of shots.

Groups of interceptors were to be housed in orbital modules. Hover testing was completed in and demonstrated integration of the sensor and propulsion systems in the prototype SBI.

It also demonstrated the ability of the seeker to shift its aiming point from a rocket's hot plume to its cool body, a first for infrared ABM seekers.

Final hover testing occurred in using miniaturized components similar to what would have actually been used in an operational interceptor. These prototypes eventually evolved into the Brilliant Pebbles program.

Brilliant Pebbles was a non-nuclear system of satellite-based interceptors designed to use high-velocity, watermelon-sized, teardrop-shaped projectiles made of tungsten as kinetic warheads.

The project was conceived in November by Lowell Wood at Lawrence Livermore National Laboratory. The Pebbles were designed in such a way that autonomous operation, without further external guidance from planned SDI sensor systems, was possible.

John H. Nuckolls, director of Lawrence Livermore National Laboratory from to , described the system as "The crowning achievement of the Strategic Defense Initiative".

Some of the technologies developed for SDI were used in numerous later projects. For example, the sensors and cameras that were developed and manufactured for Brilliant Pebbles systems became components of the Clementine mission and SDI technologies may also have a role in future missile defense efforts.

Though regarded as one of the most capable SDI systems, the Brilliant Pebbles program was canceled in by the BMDO. SDIO sensor research encompassed visible light , ultraviolet , infrared , and radar technologies, and eventually led to the Clementine mission though that mission occurred just after the program transitioned to the BMDO.

Like other parts of SDI, the sensor system initially was very large-scale, but after the Soviet threat diminished it was cut back. Boost Surveillance and Tracking System was part of the SDIO in the late s, and was designed to assist detection of missile launches, especially during the boost phase; however, once the SDI program shifted toward theater missile defense in the early s, the system left SDIO control and was transferred to the Air Force.

Space Surveillance and Tracking System was a system originally designed for tracking ballistic missiles during their mid-course phase.

It was designed to work in conjunction with BSTS, but was later scaled down in favor of the Brilliant Eyes program.

Brilliant Eyes was a simpler derivative of the SSTS that focused on theater ballistic missiles rather than ICBMs and was meant to operate in conjunction with the Brilliant Pebbles system.

Brilliant Eyes was renamed Space and Missile Tracking System SMTS and scaled back further under BMDO, and in the late s it became the low earth orbit component of the Air Force's Space Based Infrared System SBIRS.

The Delta program used a satellite known as Delta Star to test several sensor related technologies. Delta Star carried a thermographic camera , a long-wave infrared imager, an ensemble of imagers and photometers covering several visible and ultraviolet bands as well as a laser detector and ranging device.

The satellite observed several ballistic missile launches including some releasing liquid propellant as a countermeasure to detection.

Data from the experiments led to advances in sensor technologies. In war-fighting, countermeasures can have a variety of meanings:. Countermeasures of various types have long been a key part of warfighting strategy; however, with SDI they attained a special prominence due to the system cost, scenario of a massive sophisticated attack, strategic consequences of a less-than-perfect defense, outer spacebasing of many proposed weapons systems, and political debate.

Whereas the current United States national missile defense system is designed around a relatively limited and unsophisticated attack, SDI planned for a massive attack by a sophisticated opponent.

This raised significant issues about economic and technical costs associated with defending against anti-ballistic missile defense countermeasures used by the attacking side.

For example, if it had been much cheaper to add attacking warheads than to add defenses, an attacker of similar economic power could have simply outproduced the defender.

This requirement of being "cost effective at the margin" was first formulated by Paul Nitze in November In addition, SDI envisioned many space-based systems in fixed orbits, ground-based sensors, command, control and communications facilities, etc.

In theory, an advanced opponent could have targeted those, in turn requiring self-defense capability or increased numbers to compensate for attrition.

A sophisticated attacker having the technology to use decoys, shielding, maneuvering warheads, defense suppression, or other countermeasures would have multiplied the difficulty and cost of intercepting the real warheads.

SDI design and operational planning had to factor in these countermeasures and the associated cost. SDI failed to dissuade the USSR from investing in development of ballistic missiles.

SDI was likely seen not only as a threat to the physical security of the Soviet Union, but also as part of an effort by the United States to seize the strategic initiative in arms controls by neutralizing the military component of Soviet strategy.

The Kremlin expressed concerns that space-based missile defenses would make nuclear war inevitable. A major objective of that strategy was the political separation of Western Europe from the United States, which the Soviets sought to facilitate by aggravating allied concern over the SDI's potential implications for European security and economic interests.

The Soviet predisposition to see deception behind the SDI was reinforced by their assessment of US intentions and capabilities and the utility of military deception in furthering the achievement of political goals.

In Carl Sagan summarized what he heard Soviet commentators were saying about SDI, with a common argument being that it was equivalent to starting an economic war through a defensive arms race to further cripple the Soviet economy with extra military spending , while another interpretation was that it served as a disguise for the US wish to initiate a first strike on the Soviet Union.

Though classified at the time, a detailed study on a Soviet space-based LASER system began no later than as the Skif , a 1 MW Carbon dioxide laser along with the anti-satellite Kaskad , an in-orbit missile platform.

With both devices reportedly designed to pre-emptively destroy any US satellites that might be launched in the future which could otherwise aid US missile defense.

Terra-3 ' was a Soviet laser testing centre, located on the Sary Shagan anti-ballistic missile ABM testing range in the Karaganda Region of Kazakhstan.

It was originally built to test missile defense concepts, In , officials within the United States Department of Defense DoD suggested it was the site of a prototypical anti-satellite weapon system.

In a disguised Mir space station module was lifted on the inaugural flight of the Energia booster as the Polyus and it has since been revealed that this craft housed a number of systems of the Skif laser, which were intended to be clandestinely tested in orbit, if it had not been for the spacecraft's attitude control system malfunctioning upon separation from the booster and it failing to reach orbit.

The polyus was a prototype of the Skif orbital weapons platform designed to destroy Strategic Defense Initiative satellites with a megawatt carbon-dioxide laser.

In , a declassified CIA paper states that "In response to SDI, Moscow threatened a variety of military countermeasures in lieu of developing a parallel missile defense system".

Historians from the Missile Defense Agency attribute the term "Star Wars" to a Washington Post article published March 24, , the day after the speech, which quoted Democratic Senator Ted Kennedy describing the proposal as "reckless Star Wars schemes.

In addition, the American media's liberal use of the moniker despite President Reagan's request that they use the program's official name did much to damage the program's credibility.

Gerold Yonas, described the name "Star Wars" as an important tool for Soviet disinformation and asserted that the nickname gave an entirely wrong impression of SDI.

Jessica Savitch reported on the technology in episode No. The demonstration was perhaps the first televised use of a weapons grade laser.

No theatrical effects were used. The model was actually destroyed by the heat from the laser. The model and the laser were realized by Marc Palumbo, a High Tech Romantic artist from the Center for Advanced Visual Studies at MIT.

Ashton Carter , then a board member at MIT , assessed SDI for Congress in , saying there were a number of difficulties in creating an adequate missile defense shield, with or without lasers.

Carter said X-rays have a limited scope because they become diffused through the atmosphere, much like the beam of a flashlight spreading outward in all directions.

This means the X-rays needed to be close to the Soviet Union, especially during the critical few minutes of the booster phase, for the Soviet missiles to be both detectable to radar and targeted by the lasers themselves.

Opponents disagreed, saying advances in technology, such as using very strong laser beams, and by "bleaching" the column of air surrounding the laser beam, could increase the distance that the X-ray would reach to successfully hit its target.

Physicists Hans Bethe and Richard Garwin , who worked with Edward Teller on both the atomic bomb and hydrogen bomb at Los Alamos , claimed a laser defense shield was unfeasible.

They said that a defensive system was costly and difficult to build yet simple to destroy, and claimed that the Soviets could easily use thousands of decoys to overwhelm it during a nuclear attack.

They believed that the only way to stop the threat of nuclear war was through diplomacy and dismissed the idea of a technical solution to the Cold War , saying that a defense shield could be viewed as threatening because it would limit or destroy Soviet offensive capabilities while leaving the American offense intact.

In March , Bethe coauthored a page report for the Union of Concerned Scientists that concluded "the X-ray laser offers no prospect of being a useful component in a system for ballistic missile defense.

In response to this when Teller testified before Congress he stated that "instead of [Bethe] objecting on scientific and technical grounds, which he thoroughly understands, he now objects on the grounds of politics, on grounds of military feasibility of military deployment, on other grounds of difficult issues which are quite outside the range of his professional cognizance or mine.

On June 28, , David Lorge Parnas resigned from SDIO's Panel on Computing in Support of Battle Management, arguing in eight short papers that the software required by the Strategic Defense Initiative could never be made to be trustworthy and that such a system would inevitably be unreliable and constitute a menace to humanity in its own right.

Another criticism of SDI was that it would require the United States to modify previously ratified treaties.

The Outer Space Treaty of , which requires "States Parties to the Treaty undertake not to place in orbit around the Earth any objects carrying nuclear weapons or any other kinds of weapons of mass destruction, install such weapons on celestial bodies, or station such weapons in outer space in any other manner" [84] and would forbid the US from pre-positioning in Earth orbit any devices powered by nuclear weapons and any devices capable of "mass destruction".

Only the space stationed nuclear pumped X-ray laser concept would have violated this treaty, since other SDI systems, did not require the pre-positioning of nuclear explosives in space.

Kisumu city manager gives Railways ultimatum on demolitions Says consultation was not done. Not a party!

We're ready for Ruto's ouster motion - Duale Duale said impeaching the DP is not an easy matter like holding a birthday party.

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Uhuru, Ruto showdown as Parliament resumes. Go all out to sweeten BBI, trash Ruto - Joho Governor calls emergency meeting over BBI in Mombasa to counter DP Ruto.

Raila and Ruto step up BBI battle for Kenyans' hearts, minds Raila tells Ruto to stop raising questions, take a stand and lead the 'No' vote.

Raila's big Kisumu meet to firm up bastion More than 1, delegates are expected at the meeting at Ciala Resort in Kisumu.

Uhuru, Ruto showdown as Parliament resumes Savula says bid to impeach Ruto has the backing of Uhuru, Raila. Siaya becomes first county to pass BBI Bill Draft bill was passed during a special sitting gazetted by Speaker George Okode.

Inside Uhuru, Raila's plot to get 28 counties endorse BBI Already, the two leaders are sure of bagging at least 28 out of the 47 assemblies.

What next for BBI bill in county assemblies? Fight over BBI popularisation strategy detrimental BBI should not be reduced to a political mobilisation tool for succession politics.

Sagana III meeting will balkanize the country deeper Attacks on Ruto will snowball to a dangerous level that may resurrect the ghosts of Pro-Ruto assemblies pressured to pass BBI Bill Most governors are Ruto allies but Tolgos leads campaigns to convince MCAs.

Take charge of your future - Uhuru urges youth The youth assured the head of state that they will stand firm behind him in support of THE STAR PODCASTS.

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Summary for The binary nature of the SA search results in a favorable logarithmic scaling of the search time with the reference genome length, allowing fast searching even against large genomes.

Schematic representation of the Maximum Mappable Prefix search in the STAR algorithm for detecting a splice junctions, b mismatches and c tails.

In addition to detecting splice junctions, the MMP search, implemented in STAR, enables finding multiple mismatches and indels, as illustrated in Figure 1 b.

If the MMP search does not reach the end of a read because of the presence of one or more mismatches, the MMP s will serve as anchors in the genome that can be extended, allowing for alignments with mismatches.

In some cases, the extension procedure does not yield a good genomic alignment, which allows identification of poly-A tails, library adapter sequences or poor sequencing quality tails Fig.

The MMP search is performed in both forward and reverse directions of the read sequence and can be started from user-defined search start points throughout the read sequence, which facilitates finding anchors for reads with errors near the ends and improves mapping sensitivity for high sequencing error rate conditions.

Besides the efficient MMP search algorithm, uncompressed SAs also demonstrate a significant speed advantage over the compressed SAs implemented in many popular short read aligners Supplementary Section 1.

This speed advantage is traded off against the increased memory usage by uncompressed arrays, which is assessed further in Section 3.

In the second phase of the algorithm, STAR builds alignments of the entire read sequence by stitching together all the seeds that were aligned to the genome in the first phase.

We found that an optimal procedure for anchor selection is through limiting the number of genomic loci the anchors align to.

All the seeds that map within user-defined genomic windows around the anchors are stitched together assuming a local linear transcription model. The size of the genomic windows determines the maximum intron size for the spliced alignments.

A frugal dynamic programming algorithm see Supplementary Section 1. Importantly, the seeds from the mates of paired-end RNA-seq reads are clustered and stitched concurrently, with each paired-end read represented as a single sequence, allowing for a possible genomic gap or overlap between the inner ends of the mates.

This is a principled way to use the paired-end information, as it reflects better the nature of the paired-end reads, namely, the fact that the mates are pieces ends of the same sequence.

This approach increases the sensitivity of the algorithm, as only one correct anchor from one of the mates is sufficient to accurately align the entire read.

If an alignment within one genomic window does not cover the entire read sequence, STAR will try to find two or more windows that cover the entire read, resulting in a chimeric alignment, with different parts of the read mapping to distal genomic loci, or different chromosomes, or different strands Supplementary Fig.

STAR can find chimeric alignments in which the mates are chimeric to each other, with a chimeric junction located in the unsequenced portion of the RNA molecule between two mates.

STAR can also find chimeric alignments in which one or both mates are internally chimerically aligned, thus pinpointing the precise location of the chimeric junction in the genome.

An example of the BCR-ABL fusion transcript detection from the K erythroleukemia cell line is given in the Supplementary Section 1. The stitching is guided by a local alignment scoring scheme, with user-defined scores penalties for matches, mismatches, insertions, deletions and splice junction gaps, allowing for a quantitative assessment of the alignment qualities and ranks see Supplementary Section 1.

The stitched combination with the highest score is chosen as the best alignment of a read. For multimapping reads, all alignments with scores within a certain user-defined range below the highest score are reported.

Although the sequential MMP search only finds the seeds exactly matching the genome, the subsequent stitching procedure is capable of aligning reads with a large number of mismatches, indels and splice junctions, scalable with the read length.

This characteristic has become ever more important with the emergence of the third-generation sequencing technologies such as Pacific Biosciences or Ion Torrent that produce longer reads with elevated error rates.

First, we used simulated data to evaluate performance of STAR and compare it with other RNA-seq mappers. Simulations allow for a precise calculation of false-positive and -negative rates, although artificial error models, used to generate simulated reads, may not adequately represent experimental errors.

We used a simulated dataset from a recent study Grant et al. Various types of genomic variations and sequencing errors were introduced to mimic real RNA-seq data.

The latest available versions of STAR 2. Because the TopHat2 2. We found that the new version yields a slightly better accuracy and faster mapping speed Supplementary Section 2.

All aligners were run in the de novo mode, i. Note that running comparison between mappers with their default parameters is a reasonable and commonly accepted practice, as all considered aligners were, by default, optimized for mammalian genomes and recent RNA-seq data.

ROC curves Fig. All aligners exhibit desirable steep ROC curves at high values of detection threshold. At the lowest detection threshold of 1 read per junction, STAR exhibits the lowest false-positive rate while achieving high sensitivity.

Supplementary Figure S5 shows the same analysis for a low error rate-simulated dataset, which yields similar conclusions.

True-positive rate versus false-positive rate ROC-curve for simulated RNA-seq data for STAR, TopHat2, GSNAP, RUM and MapSplice. Different accuracy metrics for splice junction detection with respect to the Gencode 7 Harrow et al.

Although all aligners detect a similar number of annotated junctions Fig. The percentage of the unannotated among all detected junctions is plotted in Figure 3 b as a function of detection threshold.

Because all aligners show similar sensitivities to annotated junctions, the proportion of annotated among all detected junctions may serve as a surrogate of precision.

STAR, RUM and TopHat2 perform similarly, while GSNAP exhibits lower precision at a lower detection threshold, and MapSplice shows unusual non-monotonic and non-saturating behavior, which was also noted in Zhang et al.

Pseudo-ROC curve, i. All aligners except MapSplice perform similarly at high values of the detection threshold. Various accuracy metrics for splice junction detection in the experimental RNA-seq data.

The color-coding scheme for mappers is the same in all plots.

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